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华健

职称:  教授,博导

办公地址:理科楼C801 

联系方式: jh299@cornell.edu

 

个人简介:

华健,复旦大学生物学学士,中科院上海植物生理研究所植物学硕士,美国加州理工大学(Caltech)生物学博士,麻省理工大学(MIT)白头(Whitehead)研究所博士后。现为南京农业大学教授美国康奈尔(Cornell)大学植物生物学系教授,博士生导师。

实验室主要研究方向:

1)植物抗病机理,尤其是抗病基因(R)表达及功能调控,利用分子遗传手段克隆R基因的重要调控基因,并对基因功能和调控网络进行解析;

2)植物温敏机理,利用植物自然变异和诱导突变,解析温度分子信号在植物中的传导途径及植物温度适应的分子机制;

3)非生物逆境与植物抗病性互作的分子机制,解析发掘植物抗病信号通路中对环境敏感的关键因子,为植物品种改变和植物育种筛选耐逆性状提供分子依据。

欢迎对上述研究方向感兴趣的同学报考研究生、联系实习和SRT

个人主页:

http://plantbio.cals.cornell.edu/people/jian-hua

研究论文:

1.      Yin X#, Zou B#, Hong X, Gao M, Yang W, Zhong X, He Y, Kuai P, Lou Y, Huang J, Hua J*, He Z* (2018) Rice copine genes OsBON1 and OsBON3 function as suppressors of broad-spectrum disease resistance. Plant Biotechnol J

2.      Wang X#, Zou B#, Shao Q#, Cui Y, Lu S, Zhang Y, Huang Q, Huang J*, Hua J * (2018) Natural variation reveals that OsSAP16 controls low-temperature germination in rice. Journal of experimental botany 69: 413-421

3.      Zou B#, Ding Y#, Liu H, Hua J* (2017) Silencing of copine genes confers common wheat enhanced resistance to powdery mildew. Molecular plant pathology

4.      Zou B, Sun Q, Zhang W, Ding Y, Yang DL, Shi Z, Hua J* (2017) The Arabidopsis Chromatin-Remodeling Factor CHR5 Regulates Plant Immune Responses and Nucleosome Occupancy. Plant & cell physiology 58: 2202-2216

5.      Yang DL, Shi Z, Bao Y, Yan J, Yang Z, Yu H, Li Y, Gou M, Wang S, Zou B, Xu D, Ma Z, Kim J, Hua J* (2017) Calcium Pumps and Interacting BON1 Protein Modulate Calcium Signature, Stomatal Closure, and Plant Immunity. Plant physiology 175: 424-437

6.      Zhang Y#, Zou B#, Lu S#, Ding Y, Liu H, Hua J* (2016) Expression and promoter analysis of the OsHSP16.9C gene in rice. Biochemical and biophysical research communications 479: 260-265

7.      Zou BH#, Hong XX#, Ding Y, Wang X, Liu H, Hua J* (2016) Identification and analysis of copine/BONZAI proteins among evolutionarily diverse plant species. Genome 59: 565-573

8.      Zou BH#, Yang DL#, Shi ZY#, Dong HS, Hua J* (2014) Monoubiquitination of Histone 2B at the Disease Resistance Gene Locus Regulates Its Expression and Impacts Immune Responses in Arabidopsis. Plant Physiol 165: 309-318

9.       Hua J*  (2013) Modulation of plant immunity by light, circadian rhythm, and temperature. Curr Opin Plant Biol. 16:406-413.

10.  Bao Z, Yang H,  Hua J*  (2013) Perturbation of cell cycle regulation triggers plant immune response via activation of disease resistance genes. PNAS, 110:2407-2412.

11.  Zhu Y, Mang HG, Sun Q, Hipps A, and  Hua J*  (2012) Gene discovery using mutagen-induced polymorphisms and deep sequencing: application to plant disease resistance. Genetics, 192:139-146.

12.  Mang HG, Qian W, Zhu Y, Qian J, Kang H, Klessig DF, and  Hua J*  (2012) ABA deficiency antagonizes high temperature inhibition of disease resistance through enhancing nuclear accumulation of R proteins SNC1 and RPS4. Plant Cell, 24:1271-1284.

13.  Gou M and  Hua J*  (2012) Complex regulation of an R gene SNC1 revealed by auto-immune mutants. Plant Signal Behav. 7:213-216.

14.  Gou M, Shi Z, Zhu Y, Bao Z, Wang G, and  Hua J* . (2012) The F-box protein CPR1/CPR30 negatively regulates R protein SNC1 accumulation. Plant J 69, 411-420.

15.  Zhu Y, Yang H, Mang HG, and  Hua J*  (2011) Induction of BAP1 by a moderate decrease in temperature is mediated by ICE1 in Arabidopsis. Plant Physiol, 155, 580-588.

16.  Zhu Y, Qian W, and  Hua J*  (2010) Temperature modulates plant defense responses through NB-LRR proteins. PLoS Pathog, 6: e1000844.

17.  Li Y, Gou M, Sun Q, and  Hua J*  (2010) Requirement of calcium binding, myristoylation, and protein-protein interaction for the copine BON1 function in Arabidopsis. J Biol Chem, 285, 29884-29891.

18.   Hua J*  (2009) From freezing to scorching, transcriptional responses to temperature variations in plants. Curr Opin Plant Bio 12:568–573.

19.  Wang Y, Bao Z, Zhu Y, and  Hua J*  (2009) Analysis of temperature modulation of plant defense against biotrophic microbes. MPMI, 22: 498-506.

20.  Wang Y and Hua J*  (2009) A moderate decrease in temperature induces COR15a expression through the CBF signaling cascade and enhances freezing tolerance. Plant J, 60: 340-349.

21.  Li Y, Pennington BO, and  Hua J*  (2009) Multiple R-like genes are negatively regulated by BON1 and BON3 in Arabidopsis. MPMI, 22: 840-848.

22.  Yang S, Yang H, Grisafi P, Sanchatjate S, Fink GR, Sun Q, and  Hua J*  (2006). The BON/CPN gene family represses cell death and promotes cell growth in Arabidopsis. Plant J, 45: 166-179.

23.  Yang H, Yang S, Li Y, and  Hua J*  (2007) The Arabidopsis BAP1 and BAP2 genes are general inhibitors of programmed cell death. Plant Physiol, 145: 135-146.

24.  Li Y, Yang S, Yang H, Hua J (2007) The TIR-NB-LRR gene SNC1 is regulated at the transcript level by multiple factors. Mol Plant Microbe Interact. 20(11):1449-1456.

25.  Yang H, Li Y, and  Hua J*  (2006) The small C2 protein BAP1 negatively regulates cell death and defense response in Arabidopsis. Plant J, 45: 166-179.

26.  Yang S and  Hua J*  (2004) A haplotype-specific resistance gene regulated by BON1 mediates temperature-dependent growth control. Plant Cell, 16: 1060-1071.

27.  Hua J, Grisaffi P, Cheng, SH, Fink GR. (2001) Plant growth homeostasis is controlled by the Arabidopsis BON1 and BAP1 genes. Genes Dev 15:2263-2272.

28.  Hua J, Meyerowitz EM. (1998) Ethylene responses are negatively regulated by a receptor gene family. Cell 94:261-271.

29.  Hua J, Sakai H, Chen QG, Nourizadeh S, Bleecker AB, Ecker JR, Meyerowitz EM. (1998) EIN4 and ERS2 are two members of the putative ethylene receptor gene family. Plant Cell 10:1321-1332.

30.  Sakai H, Hua J, Chen QG, Chang C, Mderano L, Bleecker AB, Meyerowitz EM. (1998) ETR2 is an ETR1-like gene involved in ethylene signaling in Arabidopsis. PNAS 95:5812-5817.

31.  Hua J, Sakai H, Meyerowitz EM. (1997) The ethylene receptor gene family in Arabidopsis. in Biology and Biotechnology of the Plant Hormone Ethylene, 71-76. Kluwer Academic Publishers.

32.  Hua J, Chang C, Sun Q, Meyerowitz EM. (1995) Ethylene insensitivity conferred by Arabidopsis ERS gene. Science 269:1712-1714.